taxonID	type	description	language	source
292E87EAFFEFFF83FF1E5AC8391D1FE5.taxon	description	In contrast to P 47 Rec, both HPX 15 and APN 1 were highly diverse at the amino acid level. Phylogenetic analysis supported multiple distinct groups for HPX 15 (bootstrap values> 70) but not for APN 1 (bootstrap values <70). Te observed subspecies differentiation in HPX 15 indicates the potential for this gene to serve as a driver of selection on its matching P. falciparum gene in the parasite. Further investigation of this locus coupled with the identification of its corresponding P. falciparum surface proteins will elucidate whether vector-population-mediated selective pressure is occurring. We anticipate detecting signatures of balancing selection in the HPX 15 ligand (s) protein within P. falciparum populations across Africa due to the subpopulation variation observed at this locus on An. gambiae.	en	Gunarathna, Isuru, Spear, Joseph D., Carter, Tamar E. (2024): Multi-locus investigation of AnopheLeS-mediated selective pressure on PLaSModiUM FaLCiparUM in Africa. Parasites & Vectors (530) 17 (1): 1-16, DOI: 10.1186/s13071-024-06604-y, URL: https://doi.org/10.1186/s13071-024-06604-y
292E87EAFFEEFF82FF1E5B89390D19E5.taxon	description	Given that Pfs 47 in African P. falciparum populations exhibited signals of neutral evolution in relation to the current sympatric vector populations (An. gambiae, An. funestus, etc.), we aimed to investigate how the evolution of Pfs 47 might be influenced by the introduction of An. stephensi. As an initial step, we examined the P 47 Rec ortholog in An. stephensi. Since the P 47 Rec coding sequence in An. gambiae in Africa was fully conserved, we wanted to investigate the number of amino acid changes in P 47 Rec ortholog in invasive An. stephensi. We compared the amino acid sequence of the P 47 Rec ortholog in An. stephensi from Ethiopia with the An. gambiae sequence and found 18 amino acid differences. Tese findings combined with phylogenetic analysis indicating differentiation between An. stephensi and the African species (An. gambiae bootstrap value = 100 and An. funestus bootstrap value = 100) support the potential for new P. falciparum haplotype compatibilities in Africa with the arrival, spread, and establishment of the invasive An. stephensi. In addition, the phylogenetic analysis revealed a close relationship between P 47 Rec in the invasive An. stephensi and the SDA 500 An. stephensi strain (bootstrap = 100). Te SDA 500 strain is known to be highly susceptible to both I 248 L haplotypes in Pfs 47 in P. falciparum [18]. If the Pf 47 Rec was the gene that underwent artificial selection leading to higher susceptibility, it is possible the same patterns of susceptibility would be observed in An. stephensi with the similar P 47 Rec sequence. Terefore, the presence of similar P 47 Rec sequences (leading to high susceptibility) in the invasive An. stephensi may facilitate the gradual emergence of more Pfs 47 haplotypes in Africa. However, other genes may also influence the susceptibility of the SDA 500 strain. To accurately determine the characteristics of An. stephensi — Plasmodium compatibility in Ethiopia, experimental infections are necessary to validate these hypotheses.	en	Gunarathna, Isuru, Spear, Joseph D., Carter, Tamar E. (2024): Multi-locus investigation of AnopheLeS-mediated selective pressure on PLaSModiUM FaLCiparUM in Africa. Parasites & Vectors (530) 17 (1): 1-16, DOI: 10.1186/s13071-024-06604-y, URL: https://doi.org/10.1186/s13071-024-06604-y
