Radix Scutellariae
publication ID |
https://doi.org/ 10.1371/journal.pone.0175751 |
persistent identifier |
https://treatment.plazi.org/id/FF1F5B0C-FFB5-425F-FDE6-6FA98A76FACB |
treatment provided by |
Felipe |
scientific name |
Radix Scutellariae |
status |
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Hierarchical cluster analysis of the different types of Radix Scutellariae View in CoL by 26 NA inhibitory activity compounds
Hierarchical cluster analysis (HCA) is defined as a statistical method to analyze and cluster data by measuring the similarity in samples. HCA is preferential to cluster objects with highest similarities into one group. HCA was also applied to distinguish the different HM samples [ 25]. The 18 RS samples were assayed with HCA according their concentration of 26 compounds screened with UPLC/Q-TOF-MS-FC ( Fig 3 View Fig 3 ) HCA dendrogram ( Fig 7 View Fig 7 ) showed that 18 RS samples were classified into 4 groups based on concentration and NA inhibitory bioactivity of each sample ( Fig 3 View Fig 3 , Table 6). The first group (group I) contains the most biennially cultivated RS, including S10, S14, S9, S1, S11, S2, and S12. Moreover, the second group (group II) contains the perennially (3 years or more) cultivated RS, inducing S3, S8, S6, S7, S4, S5 and S13. This result demonstrated that component concentration and NA inhibitory bioactivity in RS extract were distinct between biennially cultivated and the perennially (3 years or more) cultivated RS. Group III consisted of the three wild RS (S15, S16 and S17) samples. It implied that the effects of wildness on RS contents correlated with the age of RS. The sample S18, from plateau Area, was clustered into group IV individually. These results suggest that high altitude climate may have a special role on the chemical contents of RS. From HCA methods, it was indicated that the influence of origins on the quality of RS was more than that of cultivated time.
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